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Junk : A Journey Through the Dark Matter of the Genome

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undefinedFor decades after the identification of the structure of , scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk that are involved with a number of intractable diseases. Our increasing knowledge of junk has led to innovative research and approaches that may finally ameliorate some of these conditions. Junk can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to sw off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have engendered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk , and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field.

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